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Pragmatic trials are studies designed to inform the real-world practice of clinical. They are usually focused on practical aspects of the research design, like recruitment and consent in adherence, as well as the use of standard equipment.

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Pragmatic Software, a software firm, offers a variety of casino games for online gambling platforms. Pragmatic's iGaming software is used by leading operators and land based casinos. The company provides front-end design tools, analysis, promotions, marketing payment systems, security, customer support and bug reporting. Additionally, the company provides its users a safe environment that features high-quality graphics and gaming.

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Gates of Olympus, a new release by the company, transports players into the realm of the ancient Greek gods, where Zeus oversees all the action. This high-volatility slot game has Pay Anywhere option that rewards players when they hit 8 or more identical symbols anywhere in the reels. It also comes with a lucrative Free Spins feature with multipliers that can go up to 500x the amount bet.

Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This type of heterogeneity which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However too much heterogeneity could result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gaming experience as well as a broad range of virtual betting options. The company has also developed numerous interactive game shows that make online gambling fun. Some of these shows have live hosts, whereas others are hosted by prominent personalities from the industry.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. It has established itself as one of the top gaming platforms for casinos despite its relatively young age. The latest releases include Wolves, a 5-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be a great way to identify the causality between an intervention and its results. However, they should not, be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.